Sung Min Han

Sung Min Han, Ph.D.

Assistant Professor

Department: MD-BIOLOGY OF AGING
Business Phone: (352) 273-5682
Business Email: han.s@ufl.edu

About Sung Min Han

Dr. Han completed his B.S. education in Biotechnology in the Republic of South in 2000. He completed three years of military service in the Republic of Korea Air Force. During master’s training from 2001 to 2003 under the mentorship of Dr. Hyeon-Sook Koo at Yonsei University, South Korea, Dr. Han investigated the role of mitochondria in aging using the nematode C. elegans as a genetic and in vivo model animal. He completed his Ph.D. training in 2012 under the mentorship of Dr. Michael Miller at the University of Alabama at Birmingham Medical School. During his Ph.D. training, he continued to use C. elegans to investigate novel signaling mechanisms that link abnormal mitochondrial function to the mechanisms of amyotrophic lateral sclerosis, a neurodegenerative disorder characterized by a progressive loss of motor neurons. After training in a neurodegenerative disorder, Dr. Han became interested in understanding how the nervous system can restore its function after damage. To this end, Dr. Han joined Dr. Marc Hammarlund’s lab at Yale University to investigate the molecular and cellular mechanisms underlying axon regeneration after neuronal injury. Dr. Han joined the University of Florida in 2018 as an Assistant Professor. He is the Course Director of GMS6893 – Clinical and Translational Science Seminar Series, GMS6622 – Mitochondrial Biology in Aging and Disease, and GMS6771 – Clinical Neuroscience of Aging.

Related Links:

Teaching Profile

Courses Taught
2020-2023
GMS6893 Clinical and Translational Science Seminar Series
2020-2023
GMS6622 Mitochondrial Biology in Aging and Disease
2021-2023
GMS6771 Clinical Neuroscience of Aging
2022-2023
GMS6485 Population Based Research on Aging

Research Profile

My long-term research goal is to understand (i) how the nervous system retains its function and integrity throughout its lifespan and (ii) how it affects organismal aging and health. My current research goals are to investigate:i) how aging neurons regulate mitochondrial dynamics and localization in response to local demand and injury; ii) how mitochondria control nuclear gene expression in two key conditions, including aging and injury; iii) how mitochondria respond to environmental stress and affect organismal aging and health; iv) how mitochondria stress in the nervous system modulate organismal lifespan and healthspan. We utilize the nematode C. elegans as a powerful genetic and in vivo model to answer these questions.

Open Researcher and Contributor ID (ORCID)

0000-0001-7442-754X

Publications

2023
The role of mitochondria in the recovery of neurons after injury
Neural Regeneration Research. 18(2):317-318 [DOI] 10.4103/1673-5374.343907. [PMID] 35900413.
2021
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.
GeroScience. 43(2):691-707 [DOI] 10.1007/s11357-021-00327-z. [PMID] 33527323.
2021
Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells
Toxicology. 461 [DOI] 10.1016/j.tox.2021.152924.
2021
Distinct temporal actions of different types of unfolded protein responses during aging.
Journal of cellular physiology. 236(7):5069-5079 [DOI] 10.1002/jcp.30215. [PMID] 33345326.
2021
Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation.
Journal of cellular signaling. 2(3):172-180 [PMID] 34557866.
2021
Iron homeostasis and organismal aging.
Ageing research reviews. 72 [DOI] 10.1016/j.arr.2021.101510. [PMID] 34767974.
2020
Editorial: Germline Development: From Germline Stem Cells to Gametes
Frontiers in Cell and Developmental Biology. 8 [DOI] 10.3389/fcell.2020.00650. [PMID] 32850795.
2020
Innovations in Geroscience to enhance mobility in older adults.
Experimental gerontology. 142 [DOI] 10.1016/j.exger.2020.111123. [PMID] 33191210.
2020
The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.
The Journal of cell biology. 219(2) [DOI] 10.1083/jcb.201807127. [PMID] 31968056.
2017
The C. elegans VAPB homolog VPR-1 is a permissive signal for gonad development.
Development (Cambridge, England). 144(12):2187-2199 [DOI] 10.1242/dev.152207. [PMID] 28634273.
2017
The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1.
Development (Cambridge, England). 144(12):2175-2186 [DOI] 10.1242/dev.152025. [PMID] 28634272.
2016
Mitochondria Localize to Injured Axons to Support Regeneration.
Neuron. 92(6):1308-1323 [DOI] 10.1016/j.neuron.2016.11.025. [PMID] 28009276.
2015
RNA ligation in neurons by RtcB inhibits axon regeneration.
Proceedings of the National Academy of Sciences of the United States of America. 112(27):8451-6 [DOI] 10.1073/pnas.1502948112. [PMID] 26100902.
2014
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
EMBO reports. 15(12):1278-85 [DOI] 10.15252/embr.201439531. [PMID] 25366321.
2013
VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
PLoS genetics. 9(9) [DOI] 10.1371/journal.pgen.1003738. [PMID] 24039594.
2012
Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.
Developmental cell. 22(2):348-62 [DOI] 10.1016/j.devcel.2011.12.009. [PMID] 22264801.
2010
MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.
Developmental biology. 342(1):96-107 [DOI] 10.1016/j.ydbio.2010.03.026. [PMID] 20380830.
2010
Sperm and oocyte communication mechanisms controlling C. elegans fertility.
Developmental dynamics : an official publication of the American Association of Anatomists. 239(5):1265-81 [DOI] 10.1002/dvdy.22202. [PMID] 20034089.
2009
DIC-1 over-expression enhances respiratory activity in Caenorhabditis elegans by promoting mitochondrial cristae formation.
Genes to cells : devoted to molecular & cellular mechanisms. 14(3):319-27 [DOI] 10.1111/j.1365-2443.2008.01276.x. [PMID] 19210547.
2008
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.
Cell. 133(6):963-77 [DOI] 10.1016/j.cell.2008.04.039. [PMID] 18555774.
2006
Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans.
Development (Cambridge, England). 133(18):3597-606 [PMID] 16914495.
2003
Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development.
FEBS letters. 555(2):250-6 [PMID] 14644423.

Grants

Sep 2021 ACTIVE
Identifying genes that regulate mitochondrial positioning at the synapse during aging
Role: Principal Investigator
Funding: AMER FEDN FOR AGING RES
Sep 2020 – Aug 2022
Understanding the role of mitochondria in the age-related decline in axon regeneration
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2019 ACTIVE
Identifying genes that regulate mitochondrial positioning at the synapse during aging
Role: Principal Investigator
Funding: AMER FEDN FOR AGING RES
Apr 2017 – Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA

Education

Postdoctoral Fellow
2018 · Yale University
PhD in Cell Biology
2012 · University of Alabama at Birmingham
Masters in Biochemistry
2003 · Yonsei University
Bachelors of Science
2000 · Chung-Ang University

Contact Details

Phones:
Business:
(352) 273-5682
Emails:
Business:
han.s@ufl.edu
Addresses:
Business Mailing:
PO Box 100273
1345 CENTER DR
GAINESVILLE FL 32610
Business Street:
1345 Center Drive
Med Sci Bldg, Rm NG-07
Gainesville FL 32610