Interim Department Chair
Charles E Wood
- Mailing Address:
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PO Box 100274
GAINESVILLE FL 32610
- Physical Address:
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1345 Center Drive RM M556
DEPARTMENT OF PHYSIOLOGY AND FUNCTIONAL GENO
GAINESVILLE FL 32610
- 2022 American journal of physiology. Regulatory, integrative and comparative physiology
- 2021 Scientific reports
- 2021 Metabolites
- 2020 Drug metabolism and disposition: the biological fate of chemicals
- 2020 The Journal of physiology
- 2020 Physiological genomics
- 2019 Frontiers in physiology
- 2019 Applied and environmental microbiology
- 2019 American journal of physiology. Regulatory, integrative and comparative physiology
- 2019 American journal of physiology. Regulatory, integrative and comparative physiology
- 2019 American journal of physiology. Endocrinology and metabolism
- 2019 PloS one
- 2018 Physiological reports
- 2018 Toxicology letters
- 2018 American journal of physiology. Regulatory, integrative and comparative physiology
- 2018 The Journal of physiology
- 2018 The Journal of physiology
- 2018 Frontiers in physiology
- 2017 Scientific reports
- 2017 AIDS (London, England)
- 2017 Frontiers in microbiology
- 2016 Clinical & experimental metastasis
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2016
Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation.Endocrinology
- 2016 Physiological reports
- 2016 Physiological reports
- 2016 The Journal of physiology
- 2016 F1000Research
- 2016 PloS one
- 2015 Reproductive Sciences
- 2015 Physiological genomics
- 2015 International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
- 2015 Reproductive Sciences
- 2015 Neonatology
- 2015 International journal of cancer
- 2015 Comprehensive Physiology
- 2015 Reproductive Sciences
- 2015 Reproductive Sciences
- 2015 Reproductive Sciences
- 2015 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 2015 Physiological reports
- 2014 Carcinogenesis
- 2014 Reproductive Sciences
- 2014 BMC genomics
- 2014 Physiological genomics
- 2014 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- 2014 Physiological reports
- 2014 Physiological genomics
- 2014 Reproductive Sciences
- 2014 Reproductive Sciences
- 2014 BMC infectious diseases
- 2014 Advances in experimental medicine and biology
- 2014 American journal of physiology. Regulatory, integrative and comparative physiology
- 2013 Journal of virology
- 2013 The FASEB's Journal
- 2013 The FASEB's Journal
- 2013 PloS one
- 2013 Breast cancer research : BCR
- 2013 Toxicologic pathology
- 2013 PloS one
- 2013 Pediatric Research
- 2013 PloS one
- 2013 Pediatric Research
- 2013 Journal of immunotoxicology
- 2013 Physiological genomics
- 2013 Retrovirology
- 2013 Toxicologic pathology
- 2013 American journal of physiology. Regulatory, integrative and comparative physiology
- 2013 International journal of cancer
- 2013 Cancer prevention research (Philadelphia, Pa.)
- 2013 Clinical obstetrics and gynecology
- 2013 Menopause (New York, N.Y.)
- 2012 Toxicological sciences : an official journal of the Society of Toxicology
- 2012 Toxicologic pathology
- 2012 Breast cancer research and treatment
- 2012 Emerging infectious diseases
- 2012 Physiological genomics
- 2012 The FASEB's Journal
- 2012 Menopause (New York, N.Y.)
- 2012 The FASEB's Journal
- 2012 PloS one
- 2012 The Journal of cardiovascular nursing
- 2012 The FASEB's Journal
- 2012 The Journal of nutrition
- 2011 Chemico-biological interactions
- 2011 Reproductive Sciences
- 2011 Reproductive Sciences
- 2011 American journal of epidemiology
- 2011 Reproduction, fertility, and development
- 2011 Neonatology
- 2011 Reproductive Sciences
- 2011 Cancer research
- 2011 Endocrinology
- 2011 Pediatric research
- 2011 Reproductive Sciences
- 2011 Reproductive sciences (Thousand Oaks, Calif.)
- 2011 Reproductive sciences (Thousand Oaks, Calif.)
- 2010 BMC infectious diseases
- 2010 Environment international
- 2010 AIDS research and human retroviruses
- 2010 PloS one
- 2010 Placenta
- 2010 Journal of neurovirology
- 2010 American journal of physiology. Regulatory, integrative and comparative physiology
- 2010 Reproductive Sciences
- 2010 Virology
- 2010 Neuroscience letters
- 2010 Reproductive Sciences
- 2010 Virology
- 2009 AIDS (London, England)
- 2009 Reproductive Sciences
- 2009 Neonatology
- 2009 Reproductive Sciences
- 2009 American journal of physiology. Regulatory, integrative and comparative physiology
- 2009 Gene expression patterns : GEP
- 2009 American journal of physiology. Regulatory, integrative and comparative physiology
- 2009 American journal of physiology. Regulatory, integrative and comparative physiology
- 2009 Virology
- 2009 The Laryngoscope
- 2009 Gene expression patterns : GEP
- 2009 Virology
- 2009 American journal of primatology
- 2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- 2008 Reproductive Sciences
- 2008 Journal of the National Cancer Institute
- 2008 American journal of physiology. Endocrinology and metabolism
- 2008 Nutrition journal
- 2008 Toxicologic pathology
- 2008 Neuroscience letters
- 2008 Toxicologic pathology
- 2008 Reproductive Sciences
- 2008 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- 2008 Journal of virology
- 2008 Endocrinology
- 2008 AIDS (London, England)
- 2008 Reproductive Sciences
- 2008 American journal of epidemiology
- 2008 Gene expression patterns : GEP
- 2008 Clinical and vaccine immunology : CVI
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2008
Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary.Neuroendocrinology
- 2008 The Journal of endocrinology
- 2008 Neuroendocrinology
- 2007 Tropical medicine & international health : TM & IH
- 2007 BMC infectious diseases
- 2007 The Journal of cardiovascular nursing
- 2007 Western journal of nursing research
- 2007 Journal of virology
- 2007 American journal of physiology. Regulatory, integrative and comparative physiology
- 2007 American journal of physiology. Regulatory, integrative and comparative physiology
- 2007 Psychoneuroendocrinology
- 2007 Experimental physiology
- 2006 Clinical cancer research : an official journal of the American Association for Cancer Research
- 2006 Retrovirology
- 2006 Neuroendocrinology
- 2006 Journal of the Society for Gynecologic Investigation
- 2006 Physiological genomics
- 2006 American journal of physiology. Regulatory, integrative and comparative physiology
- 2005 Experimental biology and medicine (Maywood, N.J.)
- 2005 Peptides
- 2005 Brain research
- 2005 Journal of the Society for Gynecologic Investigation
- 2005 Breast disease
- 2005 American journal of physiology. Regulatory, integrative and comparative physiology
- 2005 Journal of medical virology
- 2005 Retrovirology
- 2005 Journal of the Society for Gynecologic Investigation
- 2005 Journal of the Society for Gynecologic Investigation
- 2005 AIDS (London, England)
- 2005 American journal of physiology. Regulatory, integrative and comparative physiology
- 2005 American journal of physiology. Regulatory, integrative and comparative physiology
- 2004 Maturitas
- 2004 Journal of virology
- 2004 The Journal of infectious diseases
- 2004 The Journal of clinical endocrinology and metabolism
- 2004 Journal of Endocrinology
- 2004 The Journal of clinical endocrinology and metabolism
- 2004 Fertility and sterility
- 2003 Journal of the Society for Gynecologic Investigation
- 2003 Endocrinology
- 2003 Brain research
- 2003 The Journal of physiology
- 2003 American journal of physiology. Lung cellular and molecular physiology
- 2003 Brain research
- 2003 Journal of the American College of Cardiology
- 2003 The Journal of infectious diseases
- 2003 The American surgeon
- 2002 The Journal of physiology
- 2002 Journal of the Society for Gynecologic Investigation
- 2002 Resuscitation
- 2002 AIDS research and human retroviruses
- 2002 Journal of the Society for Gynecologic Investigation
- 2002 The Journal of biological chemistry
- 2002 The Journal of biological chemistry
- 2002 The Journal of physiology
- 2001 Regulatory peptides
- 2001 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 2000 Journal of the American College of Cardiology
- 1999 American Journal of Physiology
- 1999 American journal of physiology. Regulatory, integrative and comparative physiology
- 1998 Regulatory peptides
- 1997 Journal of Lipid Mediators and Cell Signalling
- 1995 Reproduction Fertility and Development
- 1995 Nursing Research
- 1995 Journal of Endocrinology
- 1993 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1993 American Journal of Physiology-Endocrinology and Metabolism
- 1993 Journal of Applied Physiology
- 1993 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1993 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1992 Journal of Developmental Physiology
- 1992 Circulation
- 1992 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1992 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1992 American Journal of Physiology-Heart and Circulatory Physiology
- 1991 Domestic Animal Endocrinology
- 1991 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1991 American Journal of Physiology
- 1991 American Journal of Physiology-Endocrinology and Metabolism
- 1991 Journal of Developmental Physiology
- 1991 Journal of Applied Physiology
- 1991 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1991 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1991 American Journal of Physiology-Endocrinology and Metabolism
- 1991 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
- 1990
- 1990 American Journal of Physiology
- 1984 Endocrinology
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Apr 2017
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Mar 2020
Therapeutic use of dichloroacetate in treatment of perinatal mitochondrial deficiency and cardiac dysfunctionNATL INST OF HLTH NICHD · Co-Investigator
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Dec 2016
ACTIVE
Effects of maternal cortisol on perinatal cardiac metabolism and functionNATL INST OF HLTH NICHD · Co-Investigator
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Feb 2016
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Jan 2019
Modeling the Fetal MicrobiomeNATL INST OF HLTH NIAID · Principal Investigator
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Aug 2013
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Jun 2020
DSR Matchng Support-Multidisciplinary Training Program in Hypertension -pj 104297UF DIV OF SPONSORED RES MATCHING FUNDS · Principal Investigator
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Jul 2013
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Jun 2020
Multidisciplinary Training Program in HypertensionNATL INST OF HLTH NHLBI · Principal Investigator
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Nov 2012
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Nov 2019
EIJI Research FundUF FOUNDATION · Principal Investigator
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Feb 2012
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Jan 2019
Fetal Cardiovascular and Endocrine Reflex ResponsesNATL INST OF HLTH NICHD · Principal Investigator
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Aug 2011
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Feb 2020
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ARTNATL INST OF HLTH NICHD · Project Manager
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Sep 2010
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Dec 2020
Physiology New Techniques**UF FOU UNRESTRICTED DONATION · Principal Investigator
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Jun 2010
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May 2016
Short-Term Training in Biomedical Research for Under-Represented MinoritiesNATL INST OF HLTH · Principal Investigator
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Dec 2008
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Dec 2015
Effects of Maternal Cortisol on Fetal and Neonatal Growth and Metabolism.NATL INST OF HLTH NICHD · Project Manager
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Feb 2006
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Jan 2021
Cade ProfessorshipUF FOUNDATION · Principal Investigator
Department Faculty
Stephen Anton Ph.D.
Sudeshna A Chatterjee PT, PhD
I am a clinician-scientist studying how the brain contributes to the control of walking and how the contributions change due to aging and neurological disorders such as stroke.
David J Clark Sc.D.
My research focuses on enhancing walking function in people with neurological impairments, particularly older adults and people post-stroke. Ongoing studies involve neurorehabilitation, neuroimaging, non-invasive brain stimulation, electrophysiology, and biomechanics. Grant funding listed below includes only projects administered by UF. For a full listing (including funding from the US Dept of Veterans Affairs) please see the attached curriculum vitae. Publications from my lab group are available at the following links for Pubmed and Google Scholar.
Sung Min Han Ph.D.
Neurons extend axons and form synapses to communicate with distant cells. These unique structures are susceptible to damage from pathological or physiological stresses. Despite their delicate structure, most neurons are not replaced, and so they must be maintained throughout the life of the animal. My long-term research goal is to understand how the nervous system maintains its function and integrity during aging. In particular, my current goal is to identify mechanisms that regulate the location and function of the mitochondria in two key neuronal conditions: injury (the regulation of axon regeneration) and maintenance (preserving normal synaptic function). In response to a range of conditions, neurons transport and position mitochondria at distinct subcellular sites within axons and synapses. Incorrect mitochondrial localization in neurons can result in functional deficits, failure of axon regeneration, and neurodegeneration. However, the mechanisms that regulate mitochondrial localization, and how mitochondrial subcellular localization supports specific neuronal functions are incompletely understood.
My specific goals are:
1) Investigate how aging neurons regulates mitochondrial dynamics in response to local demand and injury; 2) Elucidate how mitochondria control nuclear gene expression in aging neurons; 3) Discover how aging neurons maintain mitochondrial function at synapses.
Over the long term, I believe that these approaches will result in a new understanding of the mechanisms that maintain optimal function of the nervous system during aging by regulating mitochondrial function in aging/stressed neurons. My lab’s findings will provide better insight into novel therapeutic approaches to restore neuronal functional after nerve injury that can cause permanent loss of motility and disability.
Christiaan Leeuwenburgh Ph.D.
Christiaan Leeuwenburgh received his PhD from the University of Illinois, Urbana-Champagne in 1995 where his doctoral work focused on the regulation of glutathione homeostasis during chronic glutathione deficiencies and/or supplementation. He completed postdoctoral studies in Internal Medicine, Division of Geriatrics and Gerontology and Division of Atherosclerosis, Nutrition and Lipid Research at Washington University School of Medicine, Saint Louis. He became an Assistant Professor in 1998 at the University of Florida and the Director of the Biochemistry of Aging Laboratory. He was promoted to Associate Professor in 2002, Professor in 2007. In 2005 he joined the newly created Department of Aging and Geriatric Research, College of Medicine and Institute on Aging at the University of Florida. He is the Chief of the Division of Biology of Aging for the Department. Dr. Leeuwenburgh has joint faculty appointments in the Departments of Anatomy and Cell Biology, Biochemistry and Molecular Biology and a member of the department’s doctoral research faculty of the College of Medicine. Dr. Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age in rodent models. The biochemistry of aging laboratory utilizes several animal models of aging. He is conducting research on the role of apoptosis in the loss of human skeletal muscle with age and it’s role in human frailty. He has participated in NIH workshops focused on the biology of aging and geriatric research of the National Institute on Aging. He has published papers in The Journal of Biological Chemistry, American Journal of Physiology and Science. He reviews regularly for numerous journals including American Journal of Physiology, Experimental Gerontology, Biogerontology, and the Journal of Gerontology and is a section editor for the Journal of Experimental Gerontology. In 2004 he received the Nathan Shock Award from the National Institute on Aging. He received the Merck Geriatric Cardiology Research Award from the Society of Geriatric Cardiology in 1999; the National Research Service Award of the NIH from the National Institute on Aging in 1997 and 1998; a Young Investigator Award from the Oxygen Society in 1996; and held an American Heart Association Pre-doctoral Fellowship from the Illinois Affiliate from 1993 through 1995. His work on assessment of oxidative damage in aging and apoptosis has been increasingly recognized and appreciated by gerontologists worldwide.
Christiaan Leeuwenburgh’s major research focus is to understand the molecular mechanism of oxidative stress and apoptosis with age. His laboratory utilizes short and long lived animal models of aging. He is a pioneer in conducting research on the role of apoptosis in the loss of heart and skeletal muscle function with age.
Robert Mankowski Ph.D.
Dr. Robert Mankowski is an Assistant Professor at the Department of Aging and Geriatric Research. He obtained his PhD in Exercise Physiology at the Erasmus University Medical Center in Rotterdam, The Netherlands. His translational and team-science research is focused on preserving physical and cardiovascular function in older age. His research spans from investigating the effects of nutritional and exercise interventions on physical and cardiovascular function in moderately functioning older adults, to better understanding the epidemiology and pathobiology of poor long-term physical and cognitive outcomes in older survivors (including race and sex differences) of critical illness, especially sepsis. He aims to translate effective exercise (institution-based and remotely delivered) and nutritional interventions from moderately functioning older adults to poorly functioning older survivors of critical illness. His ultimate goal is to customize exercise and nutritional interventions in populations at risk of frailty, and thus improve quality of life and expand the health span.
Marco Pahor M.D.
MARCO PAHOR, M.D., is the director of the University of Florida Institute on Aging .
Pahor is an internationally recognized expert on population-based studies, clinical trials and multidisciplinary translational research in the fields of aging, disability and cardiovascular disease.
An experienced geriatrician and epidemiologist, Pahor has an excellent publication record, having authored or co-authored more than 450 papers in leading peer-reviewed journals, which have been cited by other researchers more than 5,0000 times. He has an extensive portfolio of grants from the National Institutes of Health and other agencies, and is a leader in research and education, serving as director of the Claude D. Pepper Older Americans Independence Center and of the faculty mentoring program of the UF Clinical and Translational Science Institute.
Before coming to UF in 2005, Pahor held a number of positions at Wake Forest University, including director of the Sticht Center on Aging, deputy associate dean of the office of research and head of the section on gerontology and geriatrics. His previous academic appointments were at the University of Tennessee, the National Institutes of Health, the University of Florence, Italy, and the Catholic University in Rome, where he also earned his medical degree and completed residency.
Pahor is on the Physical Exercise Task Force and the Aging Clinical Trials Advisory Panel of the National Institute on Aging. He has served as an editor for a number of academic journals, including Aging, Clinical and Experimental Research, the Journal of the American Geriatrics Society, the Journal of Gerontology: Medical Sciences and the Journal of Nutrition, Health and Aging. He has served on numerous NIH grant and program review panels.
Yi Sheng
I am working on the mechanism underlying aging with the C. elegans model, which can provide more knowledge for the aging of human beings.
Shinichi Someya Ph.D.
I am a tenured Associate Professor in the Department of Aging and Geriatric Research in the College of Medicine at the University of Florida. I received my BA from the University of California, Berkeley in 1991 and received my PhD from the University of Tokyo (Tokyo, Japan) in 2005. I then pursued my postdoctoral training in the laboratory of Dr. Tomas Prolla in the Department of Genetics at the University of Wisconsin (2005-2011). I joined the faculty in the Department of Aging and Geriatric Research at the University of Florida as a tenure-track Assistant Professor in June of 2011 and was promoted to tenured Associate Professor in July of 2016.
I have extensive experience (17~ years) in auditory neuroscience, aging and oxidative stress. Up to this point, I have published 47 peer-reviewed research papers and 6 chapter books, and of these, I have several publications in top journals such as Cell, Science, Molecular Cell, PNAS, and Journal of Neuroscience. My research focuses on understanding cochlear aging and gender differences in hearing. Currently, my research is supported by 3 NIH RO1, 1 NIH P30, and American Cancer Society grants.
At the University of Florida, I currently direct six graduate courses: GMS 6486 Biology of Aging (fall/spring/summer), SPA5102 Auditory Anatomy and Physiology (fall), SPA6581 Anatomy and Physiology of Balance (fall), SPA6581 Auditory Pharmacology (summer), and SPA6564 Communication and Aging (spring). I also teach 5 graduate courses as a lecturer, including GMS 6893 Clinical and Translational Science Institute Student Seminar (fall), GMS 6622 Mitochondrial Biology in Aging and Disease (fall), and GMS6070 Sensory Biology (spring). In my courses, I take a student-centered and interactive approach. I encourage students to participate actively.
A large part of my teaching effort is dedicated to mentoring students. I have served or currently serve as a committee member and/or mentor for 8 doctoral students and 18 undergraduate students. Up to this point, five graduate students have completed their PhD program: Mi-Jung Kim (August 2018; Role: Chair), Karessa White (Graduation date: August 2017; Role: Chair), Angela Fulbright, PhD (Graduation date: June 2016; Role: Co-Chair), and Dalian Ding, PhD (Graduation date: February 2015; Role: Co-Chair). I truly enjoy mentoring, interacting with the students in the lab, and sharing my research questions and ideas with them.
Someya Lab
http://someyalab.aging.ufl.edu/about-someya-lab/
Stephanie Wohlgemuth Ph.D.
I have been trained and have worked as a comparative physiologist with a focused on metabolic and cellular responses to environmental stress, disease and aging in a variety of species, ranging from marine annelid worms and freshwater fishes to rodents, humans and large mammals. My research expertise spans from whole animal experiments to subcellular organelle isolation and functional assessment to biochemical methodology. My teaching experience includes undergraduate courses in general and developmental biology and graduate courses in muscle physiology, mitochondrial biology, and aging biology. I have worked in leadership positions in physiology laboratories for over 15 years, and have supervised, mentored and trained over 36 undergraduate students, 2 graduate students as direct supervisor and committee chair, as well as 13 graduate students as committee member, and technicians and postdoctoral scientists. I received my Master of Science and Ph.D. Degrees from the Heinrich-Heine-University Düsseldorf, Germany, where I conducted my graduate research in the Institute of Zoophysiology under the supervision of Prof. Dr. Manfred Grieshaber. My area of research included comparative animal physiology and biochemistry, specifically the biochemical and physiological adaptations of marine invertebrate metabolism to environmental stress. I concluded my time at the Heinrich Heine University in Düsseldorf with postdoctoral research in the Institute of Zoophysiology, performing direct and indirect calorimetry on marine invertebrates exposed to hypoxia and hydrogen sulfide, and in the Institute of Genetics (PI Dr. Kimberley Henkle-Duehrsen), investigating the expression of Glutathione-S-Transferase proteins in C. elegans in response to oxidative stress. Subsequently, I continued my studies at the Romberg Tiburon Center for Environmental Studies, San Francisco State University, California, under the mentorship of Dr. Alissa Arp, on cellular responses of marine invertebrates to hydrogen sulfide exposure, using electron microscopy investigations of the body wall musculature of a marine invertebrate to examine hydrogen sulfide-induced formation of autophagic vacuoles. I then joined Dr. Christiaan Leeuwenburgh in the Biology of Aging Laboratory at the University of Florida, studying mitochondrial biology and autophagy in mammalian tissues, and the effects of pro-healthy-aging interventions such as calorie restriction, nutraceuticals and exercise. I expanded my research further and studied the effect of aging and external and endogenous stress on cellular physiology of large mammals, such as equine, cattle and sheep, with specific focus on mitochondrial biology and cellular quality control mechanisms. I have been a co-investigator on several federally funded projects investigating effects of maternal stress on mitochondrial function in the fetal heart and diaphragm using a sheep model (NIH, R21 and R01, PI: Dr. Keller-Wood); effect of mitochondrial function on muscle to meat conversion in different cattle breeds (USDA, PI: Dr. Scheffler), and effect of Resveratrol administration on leg muscle mitochondrial function in elderly humans (NIH, R01, PI: Dr. Anton). Recently, I established the Respirometry Core as part of the Metabolism and Translational Science Core at the Institute on Aging, in UF’s College of Medicine.